Everything is dependent on the specifics of the position, but as a guideline, I think it is better to be down a piece (3 points) than to be down a queen for two pieces (9 points for 6 points) because when you are down material, you typically want to keep pieces on the board and complicate the position; maybe the opponent will slip and give back the advantage.
If you are up in material, then you usually want to trade pieces and simplify into a winning endgame where the material different can be more important.
The reason I say down a piece is better than queen for 2 minor pieces is because the 9 points for 6 points imbalance means that both sides have already begun to trade pieces more and this slowly simplifies the position more... which is usually better for the side with more material.
See the title "Is queen for two pieces better than down a piece? Please explain."
Also how to play with the two pieces π Do I need to have extra pawns? What if I also hanged two pawns? Does it matter which pieces I have?
I'm guessing it's more the merrier, not that three's a crowd.