The QGA is a bit boring but effective and minimizes the amount of theory needed... I haven't found something I think is better.
Wich defense is your favourite?
As Black Kings Indian defense and Sicilian defense are the best opening.
There is no such thing as a "best" opening. There are a finite number of good openings, but there is no best.
I could go tooting that the French, Petroff, Stonewall Duch, and Classical Dutch are the best because I play them. That would be total hogwash though.
Again, THERE IS NO BEST!
I prefere sicillian but post your favourite defense