2... d6 - play the grand prix, that one tempo wasted on d6 has brutal consequences for black
2... e6 - just play the open sicilian via the chameleon variation. There's not much better against 2...e6, all the closed sicilian lines are generally excellent for black after an early d5 push, the grand prix also gets dominated for the same reason. You can choose whether to play fiancetto against the Kan setup 3... a6 and only enter the open lines against 3... Nc6 - Taimanov and Four Knights. You can avoid the wing gambit of the Kan this way. The line 3... Nc6 leads to a pretty strong d5 push against the fiancetto so I wouldn't recommend going that route. Unless you want to memorize the resulting lines very deep, I guess that could work, but personally I'd just play the open lines
2... Nc6 - kind of up to you, I'd probably play the open sicilian but fiancetto looks good too. Maybe play the chameleon and decide which you want. Grand prix / delayed Rossolimo - they score okay but if black knows what they're doing I don't think they're very good, would much rather play the real Rossolimo at this point
2... g6 - just push d4, it's some pseudo hyperaccelerated dragon line which is good for white
2... a6 - boring line but I'd probably again play the chameleon, if they wanted to play a Kan we could transpose into that depending on our repertoire, otherwise probably I'd avoid the Najdorf / improved OKelly here and play the fiancetto.
Any thoughts on when you would play one over the other?