How could the Sicilian and a Ruy Lopez be "absolute must knows" for black? Couldn't you just know one or the other?
I'm sure there is no "best" reply to 1. d4. Rather there are many good openings to choose from. None of them will get you a win, and none of them will make you lose. You get to do all that stuff on your own, that's why chess is so great.
What are the absolute must-knows for a good hand as Black? Sicilian and a good Closed Ruy Lopez are my cornerstones. However, it hard to see which reply to 1. d4 is best. Right now I use 1. ... nf6 and either play the Nimo-Indian, Gruenfeld, or KID, depending on their continuations.